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KMID : 0359320010410030311
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Korean Journal of Veterinary Research
2001 Volume.41 No. 3 p.311 ~ p.317
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Physiological effects of magnesium in the guinea pig hearts
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강형섭/Kang, Hyung Sub
장성은/김상진/김진상/Chang, Sung Eun/Kim, Shang Jin/Kim, Jin Shang
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Abstract
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In this work we have investigated the physiological effects of MgCl_2 in isolated atrium, papillary muscle, perfused heart and anesthesized guinea pig, The addition or infusion of MgCl_2(0~20 mM or Mg/kg) to perfused hearts and to anesthesized guinea pigs induced a marked and dose-dependent negative chronotropic effect. The sinoatrial node automaticity could also be reduced by MgCl_2. The addition of MgCl_2 to isolated atria and to papillary muscles induced a marked and dose-dependent negative inotropic effect. The threshold voltage could be increased by MgCl_2 in papillary muscle. Increasing MgCl_2 shortened the action potential duration (APD) in dose-dependent manner at 30%(APD_30) and 90% repolarization (APD_90) measured with conventional microelectrode technique in papillary muscle. In anesthesized guinea pig, the magnesium infusion resulted in a dose-dependent drop in blood pressure. These results suggested that magnesium is closely associated with cardiac physiological condition and exerts antiarrhythmic activities.
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KEYWORD
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#magnesium #automaticity #action potential duration #threshold #contractility
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